Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Washington
With
National Institute of General Medical Sciences (NIGMS)
In this aim, we will conduct a drug-drug interaction study evaluating the effects of 13-cis-retinoic acid on non-induced CYP2D6 activity in adolescent patients. Secondary analysis will evaluate the relationship between retinoid concentrations and CYP2D6 activity in these special populations
Age
12–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Non-pregnant
≥ 12 years
Patients with severe acne that are expected to receive isotretinoin for therapeutic reasons
You may not be if
Weight \< 80 lbs
Allergy or adverse reaction to dextromethorphan, vitamin A or isotretinoin
Pregnant or planning to become pregnant
Unable to follow isotretinoin risk evaluation and mitigation strategies (REMS) program (also known as iPLEDGE program)
Chronic or persistent cough accompanying asthma, smoking or chronic obstructive pulmonary disease,
Productive cough,
Fever,
Known kidney disease,
Known liver disease,
Diabetes
Obesity, body mass index ≥ 30 kg/m2
Bipolar disease,
Attention deficit disorder,
Social phobia,
Concurrent or use within 14 days of drugs known to interact with dextromethorphan or cytochrome P450 2D6 (CYP2D6) or drugs known to increase the risk of adverse effects from dextromethorphan
Concurrent use of any other product containing dextromethorphan
Consuming foods, beverages or dietary supplements known to interact with dextromethorphan or CYP2D6
Unable to give written informed consent/assent,
Inability to fast for 4 hours prior to study.
Wards of the State
Clareo Health | Effects of Isotretinoin on CYP2D6 Activity
