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A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT) | Clinical Trials | Clareo Health

UNKNOWN

A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)

Reduction in Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)

NCT03072979•National University Hospital, Singapore

View on ClinicalTrials.gov

Summary

Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy

Eligibility

Age

21 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age ≥21 years of age
•Proven metastatic disease, excluding haematological and germ cell neoplasms
•Life expectancy \>3 months, Eastern Cooperative Oncology group (ECOG) 0-2

Exclusion Criteria

•The patient must not have an allergy to gadolinium contrast that will limit the ability to image the tumour by MRI safely even with the use of premedication
•eGFR \< 30 mL/min or if patient is suffering from acute renal insufficiency
•Prior radiotherapy to the specified region
•Recent surgery to affected spinal levels, or patients requiring immediate surgical intervention
•Spinal instability score (SINS) \>12
•Symptomatic cord compression (Bilksy grade 2 or 3), or worsening neurological deficits
•Body weight of more than 120kg
•Pregnancy

Locations (1)

National University Hospital

Singapore, Singapore

Key Dates

Start Date

January 21, 2017

Primary Completion Date

December 31, 2017

Completion Date

December 31, 2018

Last Updated

March 8, 2017

Enrollment

ESTIMATED participants

Conditions

Spine Metastasis

Interventions

Stereotactic body radiotherapy

RADIATION

Contacts

BALAMURUGAN VELLAYAPPAN, MBBS, FRANZCR

CONTACT

67795555 bala_vellayappan@nuhs.edu.sg

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 8, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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