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COMPLETEDNANCT03071432

QUANtification of Cardiovascular Autonomic Neuropathy (CAN) and the Effects of Anaesthesia on Haemodynamics and Cerebral Perfusion

Rationale: Complications of chronic hyperglycaemia associated with Diabetes Mellitus type 2 (DM2) include macro- and microvascular angiopathy. Cerebral Autoregulation (CA), the capability of the brain...

Lead sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Collaborators

European Society of Anaesthesiology

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Willing and able to give written informed consent
•Scheduled for elective, non-cardiothoracic surgery under general anesthesia
•Age 18 years and above

Exclusion Criteria

•Day case surgery
•laparoscopic procedure
•DM type 1
•Parkinson's disease
•uncontrolled cardiac arrhythmia
•Pure autonomic failure (formerly called idiopathic orthostatic hypotension)
•Multiple system atrophy with autonomic failure (formerly called Shy-Drager syndrome)
•Addison's disease and hypopituitarism
•pheochromocytoma
•peripheral autonomic neuropathy (e.g., amyloid neuropathy, idiopathic autonomic neuropathy)
•known cardiomyopathy
•extreme left ventricle hypertrophy or ejection fraction \< 30%
•proven or suspected allergy for any of the medication used during induction of anaesthesia
•malignant hyperthermia
•unability to record transcranial doppler ultrasound due to anatomical variance.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 1, 2018Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment46

Start dateAug 2016

Last updatedFeb 1, 2018

Condition

Anesthesia Diabetes Mellitus, Type 2

Locations shown

Academic Medical Center

Amsterdam, North Holland

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 1, 2018Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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