Denosumab in Treating Patients With ER and/or PR Positive, HER2 Negative Metastatic Breast Cancer With Bone Metastases and Detectable Circulating Tumor Cells

Patients must have histologically or cytologically confirmed ER and/or PR positive, HER-2/neu negative metastatic breast cancer; they can be enrolled in any line of therapy without investigational agents and should have stable disease or a partial response (which can be determined clinically) on current systemic treatment; patients must also have pathologic OR radiographic evidence of bone metastases and \>= 5 CTCs; (Note: the pathology report that is used by the physician to determine diagnosis, will be used to determine patient eligibility; ER and PR status should be available at the time of registration)

Patients may have either measurable or non-measurable within 30 of days of registration; (lesions treated with radiation therapy must not be used as a target lesion); (Note: per Response Evaluation Criteria in Solid Tumors \[RECIST\] criteria version \[v.\] 1.1, measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension; non-measurable disease is defined as all other lesions, including small lesions \[longest diameter \< 10 mm or pathological lymph nodes with P10 to \< 15 mm short axis\] as well as truly non-measurable lesions; lesions considered truly nonmeasurable include: leptomeningeal disease, ascites, pleural or pericardial effusion, and inflammatory breast disease, lymphangitic involvement of skin or lung, abdominal masses/abdominal organomegaly identified by physical exam that is not measurable by reproducible imaging techniques)

Patients may be enrolled in any line of standard treatment (without investigational agents); the start date of current treatment should be at least two 2 weeks or more prior to registration; (Note: patients will continue to receive the planned active treatment with chemotherapy or endocrine therapy \[standard of care\] and initiate denosumab at the recommended dose for this protocol)

Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Leukocytes \>= 3,000/mcL (without growth factor)

Platelets \>= 100,000/mcL (with or without transfusion)

Hemoglobin \>= 8 (with or without transfusion)

Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (serum glutamic-oxaloacetic transaminase \[SGOT\] and serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 times institutional upper limit of normal (for patients with liver metastasis up to =\< 5 times of upper limit of normal \[ULN\] is allowed)

Bilirubin =\< 1.5 ULN (for patients with liver metastasis up to =\< 5 times of ULN is allowed)

Serum creatinine =\< 1.5 ULN

Creatinine clearance \>= 60 mL/min/1.73 m\^2 for patients with creatinine levels above institutional normal (creatinine clearance should be calculated per institutional standard)

Patients must have a serum calcium of \>= 2.0 mmol/L (8.0 mg/dL) or albumin-adjusted serum calcium =\< 2.9 mmol/L (11.5 mg/dL) within 30 days of registration; (Note: if patients are undergoing treatment for hypocalcemia and the serum calcium value at screening is \> 8.0 mg/dl, then the patient will be eligible for this study)

Females of child-bearing potential (FOCBP) and males with his or her partner must agree to use two acceptable methods of effective contraception, at study entry, for the duration of study participation, and for 5 months following completion of therapy; subjects who are surgically sterile (e.g., history of bilateral tubal ligation, hysterectomy) or whose sexual partner is sterile (e.g., history of vasectomy) are not required to use additional contraceptive measures; should a female patient become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately; likewise, if a male patient impregnates his female partner, he should inform the treating physician immediately; NOTE: a FOCBP is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:

* Has not undergone a hysterectomy or bilateral oophorectomy

* Has had menses at any time in the preceding 12 consecutive months (and therefore has not been naturally postmenopausal for \> 12 months)

FOCBP must have a negative serum OR urine pregnancy test =\< 7 days prior to registration

Ability to understand and willingness to sign a written informed consent and Health Insurance Portability and Accountability Act (HIPAA) consent document prior to registration

Willingness and ability of subject to comply to study requirements

What this study is about