Sofosbuvir and Simeprevir Versus Sofosbuvir and Ribavirin in Treatment of HCV

Exclusion Criteria

• •Total bilirubin \> 2 mg/dl.
• •serum albumin \< 2.8 g/dl.
• •INR \> 1.7.
• •platelet count \< 50000/mm3.
• •serum creatinine \> 2.5 mg/dl.
• •patients presented by ascites or hepatic encephalopathy.
• •patients with evidence of other causes of liver diseases, including hepatitis A, hepatitis B, autoimmune hepatitis, alcoholic liver disease, drug-induced hepatitis, haemochromatosis, Wilson disease or alpha-1 antitrypsin deficiency.
• •patients with any advanced systemic disease.
• •pregnancy or inability to use effective contraception in females.