Safety and Efficacy of BRM421 for Dry Eye Syndrome

Exclusion Criteria

• •Have any clinically significant slit lamp findings at Visit 1 that may include active blepharitis, meibomian gland dysfunction (MGD), lid margin inflammation or active ocular allergies that require therapeutic treatment, and/or in the opinion of the investigator may interfere with study parameters;
• •Be diagnosed with an ongoing ocular infection (bacterial, viral, or fungal), or active ocular inflammation at Visit 1;
• •Have worn contact lenses within 7 days of Visit 1 or anticipate using contact lenses during the study;
• •Have used any eye drops within 2 hours of Visit 1;
• •Have previously had laser-assisted in situ keratomileusis (LASIK) surgery within the last 12 months;
• •Be a woman of childbearing potential who is not using an acceptable means of birth control; acceptable methods of contraception