Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN)

Exclusion Criteria

• •The diagnosis of idiopathic membranous nephropathy(MN), systemic lupus erythematosus, malignancy, diabetes mellitus, severe infections or any other systemic disease known to be associated with secondary MN;
• •eGFR\<30ml/min.1.73m\*2;
• •Renal pathology showed that Tubular atrophy or Interstitial fibrosis was more than 50%;
• •The participant is allergy to tacrolimus, entecavir;
• •History of diabetes mellitus;
• •History of severe heart disease or cerebrovascular diseases;
• •Other active infection such as cytomegalovirus (CMV),Tuberculosis,Hepatitis A virus (HAV),Hepatitis C virus (HCV),Hepatitis D virus (HDV); Innate or acquired immunodeficiency; liver cirrhosis, liver malignment tumor;
• •Pregnant, trying to become pregnant or breast feeding;