Prognostic Value of Proadrenomedullin in Intra-abdominal Sepsis

Proadrenomedullin as a Severity Score and Prognostic Marker in Intra-abdominal Sepsis Research Type: Prospective, observational study. Duration: October 2016 - October 2017 Associated Medical Centers: La Paz University Hospital (Madrid), La Princesa Hospital (Madrid), Hospital del Mar (Barcelona), Hospital Clínico de Valladolid and Hospital Clínico de Valencia. Main Goal: To measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery. Secondary Goals: Make a comparison with other biomarkers (procalcitonin, lactic acid, CRP) and clinical severity scales used in standard critical practice (SAPSII, SOFA). To establish a correlation between the levels of Pro-Adrenomedullin, the time of stay in critical care units, days of mechanical ventilation and mortality. Variables: A. Demographics B. Date of admission to hospital and date of admission to critical care unit unit C. Clinical data: * Associated diseases * SAPS II * SOFA D. Intra-abdominal infection episode data * Systemic response: sepsis / septic shock * Isolated microorganisms in blood cultures and intra-abdominal fluid * Complications related to the infectious process (ARDS, need for mechanical ventilation, vasopressors, disseminated intravascular coagulation, acute renal failure, renal replacement techniques) E. Follow-up * Critical unit registration date * Date of discharge from hospital * Critical unit mortality, in-hospital mortality and 30 days mortality (assessed by telephone contact if the patient had been discharged). F. Pro-adrenomedullin levels at admission, 24 and 72 hours. As well as procalcitonin (PCT), lactic acid and polymerase Chain Reaction (PCR) levels.