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Active Not RecruitingPhase 4NCT03060434

Pentoxifylline and Lumbar Radiculopathy

The objective of this prospective controlled crossover study is to evaluate the efficacy and safety of pentoxifylline per os (800 mg daily) in the management of lumbar radiculopathy

Lead sponsor: St Joseph University, Beirut, Lebanon•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

St Joseph University, Beirut, Lebanon

Patients with lumbar radiculopathy, are recruited from senior author clinic. After verification of inclusion and exclusion criteria, patients consenting to enter the study are given 2 sequences (order randomly assigned) of treatment: Ibuprofen 600 mg bid, with paracetamol 1000 mg tid, pregabalin 75 mg bid for 15 days with pentoxifylline and 15 days without it. Basic clinical and demographical data are noted. Lumbar MRI results are also noted. Clinical evaluation of the patient is performed and included: clinical examination (including motor exam of lower limbs); pain is assessed according to Numerical rating Scale (NRS), and relative percentage of global improvement.

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Unilateral lumbar radiculopathy
•Disc hernia confirming the diagnosis with radio-clinical concordance

Exclusion Criteria

•Radicular deficit needing surgery
•Cauda equine syndrome
•Absence of radio-clinical concordance on MRI
•Contraindication for anti-inflammatory (Hypertension, renal insufficiency, gastric ulcer …)
•Previous intolerance to pentoxifylline, and/or to pregabalin and/or paracetamol
•Pregnancy
•Follow-up not possible
•Hepatic dysfunction
•History of drug abuse
•Current use of tramadol, codeine and/or morphine and its derivative
•Antidepressant use

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 21, 2025Terms

Trial snapshot

StatusACTIVE_NOT_RECRUITING

PhasePHASE4

Enrollment67

Start dateJun 2018

Last updatedMay 21, 2025

Condition

Lumbar Radiculopathy Lumbar Disc Herniation Lumbar Disc Disease

Locations shown

Hotel Dieu de France Hospital

Beirut

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 21, 2025Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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