Finding studies
Finding studies
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Lead
M.D. Anderson Cancer Center
Objectives: Primary objective: To determine the safety and relative efficacy of Chimeric antigen receptors (CAR).CD19-CD28-zeta-2A-iCasp9-IL15-transduced cord blood natural killer (CB-NK) cells in patients with relapsed/refractory CD19+ B lymphoid malignancies. Secondary Objectives: 1. To assess the overall response rate (complete and partial response rates). 2. To quantify persistence of infused allogeneic donor CAR-transduced CB-derived NK cells in the recipient. 3. To conduct comprehensive immune reconstitution studies.
Age
7–80
Sex
ALL
Healthy volunteers
Not accepted