An Active-Controlled Early Phase Study of Elpipodect (MK-8189) in Adults With Schizophrenia (MK-8189-005)

Exclusion Criteria

• •Is currently under involuntary commitment because he/she is considered a danger to himself/herself or others
• •Is unwilling to remain hospitalized for the duration of trial treatment
• •Is currently participating in or has participated in an interventional clinical research study \<=6 months prior to Screening, or has participated in more than one interventional clinical trial research study within 12 months prior to Screening
• •Is unwilling to allow audio/video taping of the Mini International Neuropsychiatric Interview for Schizophrenia and Psychotic Disorders (MINI) and/or PANSS interview at Screening and Baseline
• •Is currently being treated with and benefiting from medications with a moderate or strong inhibiting or inducing effect on Cytochrome P450 (CYP) 3A and/or CYP2C9 and/or sensitive substrates of CYP2B6
• •Has a history of malignancy \<= 5 years except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer
• •Has a body mass index \<18.5 or \>40 kg/m˄2
• •Has a history of treatment-resistant schizophrenia
• •Has a prolactin laboratory value of \>= 5 times the upper limit of normal at Screening
• •Has a known history or clinical evidence of clinically significant hepatic, cardiovascular, or renal disease, or of untreated narrow-angle glaucoma- Has ever been diagnosed with epilepsy or had any seizure disorder beyond one childhood febrile seizure
• •Has known serological evidence of human immunodeficiency virus (HIV) antibody
• •Has a history of neuroleptic malignant syndrome
• •Has a current diagnosis other than schizophrenia, or a comorbid diagnosis primarily responsible for current symptoms and functional impairment
• •Has a known history of borderline personality disorder, antisocial personality disorder, or bipolar disorder
• •Has a known history of traumatic brain injury, or Alzheimer's disease or another form of dementia
• •Currently meets DSM-5 criteria for substance abuse or alcohol use disorder
• •Is at imminent risk of self-harm or harm to others