IP ALT-803 Followed by SQ ALT-803 for Ovarian Cancer

Exclusion Criteria

• •Received any investigational agent within the 14 days before the start of ALT-803
• •Class II or greater New York Heart Association Functional Classification criteria (Appendix II) or serious cardiac arrhythmias likely to increase the risk of cardiac complications of cytokine therapy (e.g. ventricular tachycardia, frequent ventricular ectopy, or supraventricular tachyarrhythmia requiring chronic therapy)
• •Marked baseline prolongation of QT/QTc interval (e.g. demonstration of a QTc interval greater than 500 milliseconds)
• •Uncontrolled bacterial, fungal or viral infections including HIV-1/2 or active hepatitis C/B - chronic asymptomatic viral hepatitis is allowed
• •Active autoimmune disease requiring systemic immunosuppressive therapy
• •History of severe asthma and currently on chronic systemic medications (mild asthma requiring inhaled steroids only is eligible)
• •Uncontrolled hypertension: defined as ≥2 readings over 160 mmHg systolic or 110 mmHg diastolic within month prior to enrollment despite optimal anti-hypertensive medication. Patients with high readings which improve to ≤160/110 after adjustment of medications will be eligible.
• •History of pulmonary disease or abnormal pulmonary function studies
• •History of narcolepsy or any neurological condition which may impair consciousness