Preventing Systemic Inflammation After Cardiac Surgery With Alkaline Phosphatase

Exclusion Criteria

• •Already on renal replacement therapy
• •Patients with chronic kidney disease defined as estimated glomerular filtration rate \[eGFR\] \< 30 mL/min/1.73 m2 \[ CKD stage \> 3 \]
• •Patients who are pregnant or lactating
• •Concurrent enrollment in another clinical trial
• •Known allergic reaction to bovine alkaline phosphatase or patient is vegetarian or vegan
• •Patients with ongoing infections or current use of steroids
• •Patients with high-risk emergency surgery or with follow-up procedures already planned at admission (like e.g. TEVAR)