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Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS) | Clinical Trials | Clareo Health

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Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)

Functional Study of the Hypothalamus in High-resolution Magnetic Resonance Imaging (MRI) in Women With Polycystic Ovary Syndrome (PCOS): a Comparative Study

NCT03043924•University Hospital, Lille

View on ClinicalTrials.gov

Summary

The aim to evaluate whether activation of the hypothalamic-pituitary-gonadal axis in PCOS is associated with transient microstructural and metabolic changes in the female hypothalamus using MRI approaches to assess water diffusion and measure proton magnetic resonance spectra.

Eligibility

Age

19 - 30 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•For all subjects
•Aged from 19 to 30 years
•Body mass index : 18-25
•Informed consent before inclusion
•Do not smoke the 3 days before the MRI
•For Healthy volunteers subjects :
•Regular cycles (between 25 and 35 days) AND ovulatory.
•No signs of hyperandrogenism.
•Subjects desirous of taking oral contraceptives (estrogen/progestin combination).
•For the realization of the 2nd MRI: to be during the 3rd month of a treatment well followed by oestro-progestative monophasic minidose to 0,02mg of Ethinyl-oestradiol / 0,1mg Levonorgestrel.
+4 more criteria

Exclusion Criteria

•Hormone treatment within 3 months prior to inclusion (including birth control pill )
•On-going pregnancy (determined before each MRI scan visit)
•Claustrophobia
•Any metal or foreign implants (e.g., aneurysm clips, ear implants, heart pacemakers or defibrillators)
•Diabetes or known dysthyroidism.
•Current substance abuse (including smoking more than 5 cigarettes/day; determined using drug screening at the screening visit)
•Pregnancy or breastfeeding the last 3 months.
•Practice of intense physical exercise (ex jogging\> 10km) the day before the MRI.
•Person incapable of consenting, or enjoying legal protection (guardianship / curatorship).
•Unability to understand the treatment protocol

Locations (1)

Hôpital Jeanne de Flandres, CHU

Lille, France

Key Dates

Start Date

September 26, 2017

Primary Completion Date

April 15, 2022

Completion Date

April 15, 2022

Last Updated

December 11, 2025

Enrollment

ACTUAL participants

Conditions

Polycystic Ovary Syndrome

Interventions

Cyproterone Acetate + estradiol

DRUG

Levonorgestrel, Ethinyl Estradiol 0.1-0.02Mg Oral Tablet

DRUG

Glucose Profiles in Women With Polycystic Ovary Syndrome

NCT07483723

Polycystic Ovary SyndromeGlucose Profile+2 more

View study

RECRUITING

Pro- and Anti-inflammatory Cytokines in PCOS

NCT06793085

Reproductive AgePCOS (Polycystic Ovary Syndrome)

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 11, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)

Inclusion Criteria

Exclusion Criteria

Glucose Profiles in Women With Polycystic Ovary Syndrome

Pro- and Anti-inflammatory Cytokines in PCOS

Functional Proteins in Polycystic Ovary Syndrome

Multidisciplinary Diagnosis and Treatment of Polycystic Ovary Syndrome

Evaluation of the Effect of Time-Restricted Feeding and Mediterranean Diet Model in Women With Polycystic Ovary Syndrome

Treatment of Menstrual Cycle Alterations in Adolescents