Use of drug affecting metabolism, glucose, or appetite (Metformin is allowed if dose and weight are stable for at least 3 months);

history of medication changes within 4 weeks of enrollment;

active substance use;

history of cardiovascular disease, gastrointestinal disorders, bariatric surgery, epilepsy, untreated thyroid disease;

hematocrit \>2% below normal;

fasting glucose \> 125 mg/dL or hemoglobin A1c ≥ 7% ;

ALT or AST \>2.5 times upper limit of normal;

Cr \>1.5 mg/dL; hyponatremia;

pregnancy or breastfeeding;

unwilling to use medically acceptable form of contraception (females only)

follows a nonstandard diet (e.g., gluten free, pescatarian, vegetarian, vegan, Paleo, Atkins, raw diet, macrobiotic diet)

current smoking or tobacco use

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