Influence of Instaflex Advanced Supplement on Joint Function

The research procedures will be conducted at the Human Performance Laboratory (Room 1201, Plants for Human Health Institute Building, 600 Laureate Way), operated by Appalachian State University at the North Carolina Research Campus (NCRC) in Kannapolis, NC. Subjects will come here for orientation/baseline testing and then 3 other lab visits (each session will take about 30 minutes). The total amount of time study participants will be asked to volunteer for this study is about 2 hours at the Human Performance Laboratory (over a 12-week period). Participants will also take a daily supplement for 12 weeks and keep compliant with this regimen. Lab visit testing sequence: 1. First visit: 1. Consent form 2. Medical health questionnaire to verify medical history, and lifestyle habits. 3. Questionnaire for previous 4-weeks symptoms. 4. Height, weight, and percent body fat (BIA).Testing will take place behind a screened area of the lab to maintain privacy. 5. Questionnaires: WOMAC, visual pain scale, POMS. 6. Receive supplement organizer tray with 4-weeks supply (and instructions). 7. After a practice trial, study participants will walk as quickly and far as they can on a track for 6 minutes. Total distance covered in 6 minutes will be recorded. 2. 4 weeks, 8-weeks, 12 weeks (second, third, and fourth lab visits): 1. Symptoms log for previous 4-weeks symptomatology. 2. Height, weight, and percent body fat. 3. Questionnaires: WOMAC, visual pain scale, POMS. 4. Receive supplement organizer tray with 4-weeks supply (and instructions) during second and third lab visits. 5. 6-minute walk test Supplements: Supplements (Instaflex Advanced, placebo) will be contained in identical looking capsules and organized by day of the week in supplement organizer trays. Study participants will take 1 capsule each day in the morning. The placebo capsules contain magnesium stearate, an inert substance. The Instaflex Advanced supplement ingredients include: turmeric, resveratrol, Boswellia serrata, collagen, hyaluronic acid, and black pepper extract. Compliance will be monitored with bi-weekly email messages, and by counting unused capsules when the supplement trays every 4 weeks. Acetaminophen, as found in Tylenol, will be allowed as a rescue medicine for pain during the study as needed.