Leukotriene Antagonism in Recruitment of CD49d Expressing Neutrophils in Atopic Subjects

Exclusion Criteria

• •Use of systemic antihistamine in the past 5 days
• •Use of intranasal corticosteroids or intranasal antihistamines currently or in the past 2 weeks
• •Use of Montelukast currently or in the past week
• •Hypersensitivity or allergy to Montelukast
• •Inability to perform/undergo any study procedures
• •Pregnancy (by subject report) or breastfeeding
• •Confirmed or suspected immunodeficiency
• •Persistent asthma, atopic dermatitis, or any other co-morbid disease except for allergic rhinitis
• •Any symptoms of asthma in the past 2 weeks (shortness of breath, wheezing, and/or use of albuterol)
• •Fever (temperature over 99F) currently or in the past 2 weeks
• •Current or previous use of a biologic or investigational agent in the past 6 months
• •Current or past suicidal thoughts/attempts