Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Cambridge University Hospitals NHS Foundation Trust
With
University of Cambridge
Age
18–50
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Volunteers are homozygous for:
* Arm 1: The A-allele of rs6841581, they are assigned to the 'case' group. If they are homozygous for the G-allele, they are assigned to the 'control' group
* Arm 2: The G-allele of rs738409, they are assigned to the 'case' group. If they are homozygous for the C-allele, they are assigned to the 'control' group
* Arm 3: The G-allele of rs867186, they are assigned to the 'case' group. If they are homozygous for the A-allele, they are assigned to the 'control' group
Volunteers are aged between 18-50 years old
Volunteers have a BMI:
* Arm 1: Between18.5-29.9
* Arm 2: Between 25.0-39.9
* Arm 3: Between 18.5-29.9
Volunteers are willing not to consume products containing alcohol or caffeine 12 hours prior to procedures. Additionally, volunteers must agree to fast before procedures for:
* Arm 1: At least 4 hours
* Arm 2: At least 8 hours (for visit 2 only)
* Arm 3: At least 4 hours
Have given written informed consent to participate
You may not be if
Volunteers with chronic diseases, including cardiovascular diseases, liver diseases, type 1 and type 2 diabetes autoimmune diseases and cancer
Biological first-degree relatives (parents, brothers, sisters or children) who are or have suffered from one of the conditions described above
Current smokers. Ex-smokers are suitable if they stopped smoking \>10 years ago
Volunteers with a diagnosis of hypertension, or history of consistently high blood pressure readings, \>140/90 mmHg
Volunteers with a diagnosis of hypercholesterolemia, or history of consistently high cholesterol levels, e.g. total cholesterol level \>6 mmol/l
