Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans

Exclusion Criteria

• •Age \<18 and \>50
• •HbA1c ≥ 5.7%; heart or lung disease
• •acute systemic infection accompanied by fever, body aches, or swollen lymph glands
• •BMI \> 27 kg/m2
• •current dieting or weight loss efforts
• •current pregnancy or breastfeeding
• •known history of HIV/AIDS; cancer
• •biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis
• •recent blood donation
• •clinical history of stroke
• •hypertension (systolic \> 140 mmHg or diastolic \> 90 mmHg)
• •type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline
• •Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing