Age

18–50

Sex

ALL

Healthy volunteers

Accepted

Significant use of systemically-absorbed glucocorticoids currently or for an extended period of time during the prior 6 months
Current use of antihypertensive medications
Current use of metformin, or any antidiabetic medications (which could affect glucose and insulin levels)
Current use of medications known to affect dexamethasone metabolism, including phenytoin, rifampin, carbamazepine, troglitazone, and barbiturates
Active, clinically significant infection at time of visit
History of adrenal insufficiency or Cushing's syndrome
Prior or current cardiovascular disease, renal disease, or liver disease
Diabetes mellitus, pre-diabetes, impaired fasting glucose, or impaired glucose tolerance
Atrial fibrillation
Bleeding disorder or anemia
Elevated Liver Functions Tests \> 2 times upper limit of normal
Estimated glomerular filtration rate \< 60 ml/min
HbA1c \> 5.7
Abnormal sodium or potassium level
Positive pregnancy test, women of child-bearing age not practicing birth control, women who are breastfeeding

Diagnosing Natriuretic Peptide Deficiency