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Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias

NCT03035851·1 site·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Marc J Poulin, PhD, DPhil
CONTACT
403-220-8372 poulin@ucalgary.ca

Lead

University of Calgary

With

Canadian Institutes of Health Research (CIHR)

Age

50–80

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

inactive men and women aged 50-80 years (inclusive) with subjective cognitive symptoms but no dementia who have one or more vascular risk factors (see below) for ADRD;
Inactivity will be assessed with a physical activity questionnaire and defined as engagement in \<3 sessions/week of 20 min or more of vigorous exercise;
Subjective cognitive symptoms will be self-reported using the MAC-Q Memory Complaint Questionnaire, recently validated as a measure of subjective memory complaints in healthy elderly subjects, in patients with mild cognitive impairment, and in relation to AD biomarkers; participants with a score of ≥25 will be considered eligible.
Vascular risk factors for ADRD including the following:
history of hypertension;
diabetes mellitus;
obesity (body mass index (BMI) \<40 kg/m2)
elevated cholesterol;
currently smoking;
past history of coronary artery disease without recent (\<5 years) symptoms.
Participants must provide a completed PAR-Q+ form (www.csep.ca), the standard method of obtaining physician approval for participation in an exercise program. For participants without a family doctor to provide this form, we will provide information on how to find a family doctor.

You may not be if

diagnosis of a developmental handicap;
history of dementia (DSM-V criteria)\*\*;
terminal illness (life expectancy \< 1 year)
not fluent in verbal and written English;
history of stroke;
currently participating in another trial;
comorbid medical or neurological illnesses (e.g., multiple sclerosis) that would confound cognitive assessments or make trial completion unlikely (in the site investigator's opinion);
contraindication for the intervention;
contraindication for an MRI exam.
\*\*Existing or suspected dementia will be identified by medical history, cognitive impairment on the Telephone Interview for Cognitive Status (TICS-modified; score≤ 20), or impaired Instrumental Activities of Daily Living (IADL) - a response of needs assistance or dependent due to cognitive impairments on any item on the Lawton scale.

The record

StatusRecruiting

PhaseNot applicable

Taking part264

StartedJan 2017

UpdatedApr 29, 2026

Conditions

Alzheimer Disease Dementia

Where1

University of Calgary
Calgary, Alberta, Canada