Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS

Exclusion Criteria

• •Pregnancy
• •History of pacemaker implant
• •Any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI
• •History of dementia, major psychiatric diseases, or life threatening diseases
• •Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy
• •History of seizure
• •Pending litigation
• •Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy
• •Lack of ability to understand the experimental protocol and to adequately communicate in English
• •History of Traumatic Brain injury
• •Chronic Tension or Cluster Headache
• •Ongoing Cognitive Rehabilitation or Treatment of PTSD
• •Criteria for healthy veterans without Gulf War Illness headaches and pain:
• •CDC Criteria for GWI
• •Kansas Criteria for GWI
• •International Headache Society Criteria for Migraine HA w/o aura
• •Average Headache Exacerbation Intensity \>3 on 0-10 NPRS
• •Average Overall Daily Muscle Pain Intensity \>3 on 0-10 NPRS
• •Average Overall Daily Extremities Joint Pain Intensity \>3 on 0-10 NPRS
• •Headache Exacerbation/Attack ≥ 3 times/week, lasting \>4 hrs in past 3 months
• •Pregnancy
• •History of pacemaker implant
• •Any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI
• •History of dementia, major psychiatric diseases, or life threatening diseases
• •Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy
• •History of seizure
• •Pending litigation
• •Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy
• •Lack of ability to understand the experimental protocol and to adequately communicate in English
• •History of Traumatic Brain injury
• •Chronic Tension or Cluster Headache
• •Ongoing Cognitive Rehabilitation or Treatment of PTSD