The main aim of this pilot study is to examine the feasibility, tolerability, and acceptability of a computerized attention training program for children who have clinically elevated anxiety. Youth from a rural Latino community, with significant anxiety symptoms (N = 52) will be randomized to an active attention bias modification program (AMP) for four weeks or to an attention control condition (nonactive) for four weeks. Families will be assessed at baseline, mistreatment, post-treatment and 3 month followup. AMP responders will be determined by reduction on a self-report measure of anxiety and a clinician administered assessment. Community health workers (promotoras) will be trained to administer the program to youth. Data will be gathered to examine the feasibility, tolerability, and acceptability of this type of treatment and this mode of service delivery. It is hypothesized that the AMP will be feasible, tolerable, and acceptable to this underserved community sample of ethnic minority youth.
Study Design: Following ascertainment of study eligibility and completion of baseline assessment, youth will be assigned to four weeks of AMP or ACC (attention control condition). All youngsters and their families will undergo a comprehensive baseline assessment and be reassessed at mistreatment, treatment endpoint (week 4) and 3 month followup.
Screening: Youth will be recruited through various mechanisms.
1. Flyers will be posted in primary care clinics in Imperial Valley and Los Angeles County. Clinicas de Salud del Pueblo is a private, non-profit corporation providing primary care services throughout Imperial County. Flyers will be posted in the 10 primary care clinics, located in Imperial County.
2. The second method for recruiting subjects will be through physician referral from providers within the primary care systems. Prior to the study start, all pediatricians/providers will receive information about the study, symptoms of child anxiety, and the use of a short screening measure to assist in detecting child anxiety. If a provider at one of the clinics identifies a child with anxiety or a parent reports that child has symptoms consistent with anxiety (fears, worries, nervousness, unexplained somatic complaints, etc.), the provider will have the option to explain the study to the parent and give them the study brochures. Alternatively, providers, if able, can also ask parents to sign a consent to contact form, giving the research team permission to contact them directly to discuss the study.
3. Providers may also chose to refer the patient to the study promotora who will assist will explaining the study to the participant, screening, and consenting the participants.
4. Flyers will also be posted at Sun Valley Behavioral Medical Center, a private medical clinic that serves the medical and mental health needs of children, adolescents and adults in Imperial County. In this case, parents will be expected to call our research team for more information.
5. The co-PI on this study, Dr. Denise Chavira has an ongoing school based study being conducted with high school students in Imperial Valley. Given that this study covers a range of ages (8-17), we will also recruit from high schools. As part of the existing consent form (for protocol 14-000663), students are asked to check the box if they are interested in participating in future research studies. We will contact those students who have indicated interest in future studies to discuss the current project.
In all of these methods, the community health worker/promotora/e will contact the parent to conduct an initial screen. Thereafter the promotora and/or research coordinator will arrange an in person meeting with the parent and youth to review the consent with the parent and assent form with the youth and administer the eligibility measures. The initial eligibility assessments will not be conducted until all consent/assent forms have been signed and returned to the research team.
At the end of the eligibility visits, the PIs (Chavira and Chang) will review the questionnaires to determine final eligibility. Those who are eligible will process to the baseline visit where they will receive the AMP or ACC program as well as other measures. We have included a table of these measures as well as the assessment schedule in 10.1 section 1.0.
Attention Modification Program: AMP is a modified version of the dot-probe paradigm similar to the original task used by MacLeod, Mathews, and Tata. Each trial begins with a fixation cross presented in the center of the computer screen for 500 ms. The cross is then replaced by a pair of faces presented in the center of the screen for 500 ms. The face pair disappears and a probe (i.e., the letter "E" or "F") appears immediately in the location of one of the two faces. Participants will be instructed to decide whether the letter is an E or an F and press the corresponding mouse button. The letter probe will remain on the screen until the participant responds. Response latencies to identify the probe will be recorded from the onset of the presentation of the letter probe to the button press. A total of 288 training trials will be delivered each session. This paradigm has been modified to facilitate an attention bias away from threatening material. In this case, the probe always replaces the neutral face. Thus, although there will be no specific instruction to direct attention away from the threatening face, on all trials, the position of the neutral face will indicate the position of the probe.
Attention Control Condition: Like AMP, the attention control condition is a dot-probe task that begins with a fixation cross presented in the computer screen for 500ms, is followed by a pair of faces (one neutral, one threatening) for 500ms, and then a trial is completed when the face pair disappears and a probe (letter "E" or "F") appears in the location of one of the two faces. Participants will be instructed to decide whether the letter is an E or an F and press the corresponding mouse button. The letter probe will remain on the screen until the participant responds. Response latencies to identify the probe will be recorded from the onset of the presentation of the letter probe to the button press. A total of 288 training trials will be delivered each session. However, in this case, the probe replaces both the neutral and threat face 50% of the time.
Assessment. All parents and children enrolled in the study will complete assessments at baseline, mid-treatment, post-treatment and 3 month followup. Assessments will focus on feasibility outcomes and clinical outcome measures. Further, measures of moderating factors will be included in order to better understand variables (e.g., poverty, attention control, acculturation) that may suggest trends in differential treatment response within the two conditions.
