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Platelet Activation and Reactivity in Acute Exacerbations of COPD

Platelet Activation and Responsiveness in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AE-COPD)

NCT03017625•Radboud University Medical Center

View on ClinicalTrials.gov

Summary

Chronic obstructive pulmonary disease (COPD) is known for development of severe cardiovascular co-morbidities. Systemic inflammation during acute exacerbations of COPD (AE-COPD) is thought to play a role in development of cardiovascular disease. Platelets contribute to acute cardiovascular events and atherosclerosis. When platelets are activated, they form complexes with monocytes. These platelet-monocyte complexes (PMCs) are an early process in atherothrombosis and promote inflammation. In COPD, platelet function in AE-COPD is scarcely studied. This study aims to address this gap by investigating platelet function and coagulation in patients with AE-COPD and after convalescence.

Eligibility

Age

40 - 99 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•\>40 years
•Spirometry confirmed diagnosis of COPD (i.e. post-bronchodilator FEV1/FVC \< 70% and less than 12% on reversibility testing\< Lower limit of normal (LLN))
•≥10 pack years of smoking

Exclusion Criteria

•Use of anti-coagulation or other platelet function inhibitors
•Asthma
•Chronic inflammatory diseases, for example rheumatoid arthritis, psoriasis, inflammatory bowel diseases , systemic lupus erythematous (SLE)
•Malignancies

Key Dates

Start Date

January 1, 2017

Primary Completion Date

June 1, 2017

Completion Date

September 1, 2017

Last Updated

January 11, 2017

Enrollment

ESTIMATED participants

Conditions

COPD Exacerbation

Interventions

Blood is drawn

OTHER

Contacts

Floor E Aleva, MD

CONTACT

0031 24 361 03 25 floor.aleva@radboudumc.nl

Yvonne F Heijdra, MD, PhD

CONTACT

0031 24 361 03 25 yvonne.heijdra@radboudumc.nl

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COPD Exacerbation

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RECRUITINGNA

Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)

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Sleep ApneaCOPD Exacerbation+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 11, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Platelet Activation and Reactivity in Acute Exacerbations of COPD

Inclusion Criteria

Exclusion Criteria

Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD

Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)

Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease

Nasal High-Flow in COPD

Virtual Reality in COPD Exacerbation

Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting