Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Pittsburgh
With
National Heart, Lung, and Blood Institute (NHLBI)
This is a single-center, 22-week double-blind, randomized placebo-controlled cross-over trial of oral nitrite on exercise capacity and hemodynamic measurements in subjects with PH-HFpEF.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age 18 years and older
PH-HFpEF confirmed diagnosis by RHC:
Mean Pulmonary Arterial Pressure (mPAP) ≥ 25 mmHg AND
Pulmonary capillary wedge pressure (PWCP) ≥ 15 mmHg AND
Transpulmonary Gradient (TPG) ≥ 12 mmHg
You may not be if
Age less than 18 years;
SBP \> 170 or \< 110 mmHg
DBP \>95 or \< 60 mmHg
Hemoglobin A1C \> 10
Positive urine pregnancy test or breastfeeding;
Ejection Fraction (EF) \< 40%;
Dementia
End-stage malignancy
Major cardiovascular event or procedure within 6 weeks prior to enrollment
Severe valvular disease
Known chronic psychiatric or medical conditions that may increase the risk associated with study participation in the judgment of the investigator, would make the subject inappropriate for entry into this study;
Smoker
Hemoglobin \<9 g/dL
Serum creatinine \> 3.0 mg/dL
Receipt of an investigational product or device, or participation in a drug research study within a period of 15 days; RHC \< 2 weeks from study screening RHC unless clinically indicated
