CD36 in Nutrient Delivery and Its Dysfunction

Exclusion Criteria

• •Diabetes type 1 or type 2, as defined by a FPG \> 126 mg/dL a two-hour plasma glucose \> 200 mg/dL, or the use of anti-diabetic medication
• •Pulmonary hypertension
• •Use of a PDE5 inhibitor for erectile dysfunction
• •Pregnancy or breast-feeding. Women of child-bearing potential will be required to have undergone tubal ligation or to be using an oral contraceptive or barrier methods of birth control.
• •Cardiovascular disease such as myocardial infarction, presence of angina pectoris, significant arrhythmia, congestive heart failure (left ventricular hypertrophy acceptable), deep vein thrombosis, pulmonary embolism, second or third degree heart block, mitral valve stenosis, aortic stenosis or hypertrophic cardiomyopathy
• •History of serious neurologic disease such as cerebral hemorrhage, stroke, or transient ischemic attack
• •History or presence of immunological or hematological disorders
• •Any underlying or acute disease requiring regular medication which could possibly pose a threat to the subject or make implementation of the protocol or interpretation of the study results difficult
• •Treatment with chronic systemic glucocorticoid therapy (more than 7 consecutive days in 1 month)
• •History of alcohol or drug abuse
• •Mental conditions rendering a subject unable to understand the nature, scope and possible consequences of the study
• •Inability to comply with the protocol, e.g., uncooperative attitude, inability to return for follow-up visits, unlikelihood of completing the study, and investigator discretion