Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Brigham and Women's Hospital
MATCH is a non-randomized observational longitudinal study. We will recruit HIV infected adults (50 to 65 years old) and demographically matched uninfected control subjects to be followed for 4 years over the course of a 5 year study. The targeted age range of 50-65 is chosen to evaluate aging HIV infected individuals at risk for early frailty in the United States. All subjects will undergo blood draws and physical function assessment, and a subset will undergo a CT scan of muscle and will have a muscle biopsy taken.
A substudy will be performed on a subgroup of HIV-infected and HIV-uninfected men from the main cohort to measure daily physical activity by using an activity tracker.
Age
50–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Group 1: HIV positive subjects
HIV positive
English speaking
50-65 years old
On Antiretroviral therapy and an HIV viral load below 200 copies/ml
CD4 equal to or greater than 350 cells/mm3
Postmenopausal (women)
Lower extremity mobility sufficient to participate in functional assessment.
English speaking
50-65 years old
Negative for HIV (based on an HIV antibody test at Study Visit 1)
Matched to Group 1 for sex (50% W, 50% M) and age (50 - 65yo)
Postmenopausal (women)
Lower extremity mobility sufficient to participate in functional assessment.
You may not be if
Acute or serious illness within 60 days prior to entry
Use of pharmacologic doses of corticosteroids in the past 6 months.
Use of anabolic therapy in the past 6 months.
Lower extremity mobility insufficient to participate in functional assessment.
Current use (last 30 days) of anticoagulants or known bleeding disorder.
Acute or serious illness within 60 days prior to entry
Use of pharmacologic doses of corticosteroids in the past 6 months
Use of anabolic therapy in the past 6 months
Lower extremity mobility insufficient to participate in functional assessment
Current use (last 30 days) of anticoagulants or known bleeding disorder.
Clareo Health | Biomarkers for Muscle Function and Aging in Chronic HIV Infection
