Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Incyte Corporation
Age
18–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participants diagnosed with atopic dermatitis (AD) as defined by the Hanifin and Rajka criteria.
Participants with a history of AD for at least 2 years.
Participants with an Investigator's Global Assessment (IGA) score of 2 to 3 at screening and baseline.
Participants with body surface area (BSA) of AD involvement, excluding the face and intertriginous areas, of 3% to 20% at screening and baseline.
Participants who agree to discontinue all agents used to treat AD from screening through the final follow-up visit.
You may not be if
Participants with evidence of active acute or chronic infections.
Use of topical treatments for AD (other than bland emollients) within 2 weeks of baseline.
Systemic immunosuppressive or immunomodulating drugs (eg, oral or injectable corticosteroids, methotrexate, cyclosporine, mycophenolate mofetil, azathioprine) within 4 weeks or 5 half-lives of baseline (whichever is longer).
Participants with other dermatologic disease besides AD whose presence or treatments could complicate the assessment of disease (eg, psoriasis).
Participants with a history of other diseases besides dermatologic disorders (eg, other autoimmune diseases) taking treatments that could complicate assessments.
Participants with cytopenias at screening, defined as:
* Leukocytes \< 3.0 × 10\^9/L.
* Neutrophils \< lower limit of normal.
* Hemoglobin \< 10 g/dL.
* Lymphocytes \< 0.8 × 10\^9/L
* Platelets \< 100 × 10\^9/L.
Participants with severely impaired liver function (Child-Pugh Class C) or end-stage renal disease (ESRD) on dialysis or at least 1 of the following:
* Serum creatinine \> 1.5 mg/dL.
* Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥ 1.5 × upper limit of normal.
Participants taking potent systemic cytochrome P450 3A4 inhibitors or fluconazole within 2 weeks or 5 half-lives, whichever is longer, before the baseline visit (topical agents with limited systemic availability are permitted).
Participants who have previously received Janus kinase (JAK) inhibitors, systemic or topical (e.g., ruxolitinib, tofacitinib, baricitinib, filgotinib, lestaurtinib, pacritinib).
Clareo Health | A Study to Evaluate the Safety and Efficacy of Ruxolitinib Phosphate Cream Applied Topically to Adults With Atopic Dermatitis
