Safety and Efficacy of Pf-06650833 In Subjects With Rheumatoid Arthritis, With An Inadequate Response To Methotrexate

Exclusion Criteria

• •1. Subjects with a known immunodeficiency disorder or a first degree relative with a hereditary immunodeficiency.
• •2. Subjects with any of the following infections or infections history:
• •1. Any infection requiring treatment within 2 weeks prior to screening (Visit 1).
• •2. Any infection requiring hospitalization, parenteral antimicrobial therapy within 60 days, or as otherwise judged to be an opportunistic infection or clinically significant by the investigator, within the past 6 months.
• •3. Infected joint prosthesis at any time with the prosthesis still in situ.
• •4. Recurrent (more than one episode) herpes zoster or disseminated (a single episode) herpes zoster or disseminated (a single episode) herpes simplex.
• •5. Subjects will be screened for HIV. Subjects who test positive for HIV will be excluded from the study.
• •6. Subjects will be screened for hepatitis B virus infection and will be excluded if positive for hepatitis B surface antigen (HBsAg). Subjects with HBsAg negative testing but who test positive for hepatitis B core antibody (HBcAb) must have further testing for hepatitis B surface antibody (HBsAb). If HBsAb is negative, the subject will be excluded from the study.
• •7. Subjects with clinically significant active hepatic disease or hepatic impairment by laboratory assessment.
• •8. Subjects will be screened for hepatitis C virus (HCV Ab). Subjects with positive HCV Ab tests will be reflex tested for HCV ribonucleic acid (HCV RNA). Only subjects with negative HCV Ab or HCV RNA will be allowed to enroll in the study.
• •3. Evidence of active or latent, untreated or inadequately treated infection with Mycobacterium tuberculosis (TB)
• •4. Pre-existing chronic autoimmune disease.