Prospective Investigation of Multiple Sclerosis in the Three Rivers Region

You may be eligible if

• 1. Age 7 years or older
• 2. Willing and able to provide consent (for \>=18 years) or assent with permission from at least one of the child's parents (for \<18 years)
• 3. Diagnosis of multiple sclerosis or related disorders, including a first central nervous system demyelinating episode with a positive MRI scan or abnormal MRI scans characteristic of MS but no clinical symptoms of the disease
• For healthy controls:
• 1. Age 7 years or older
• 2. Willing and able to provide consent (for \>=18 years) or assent with permission from at least one of the child's parents (for \<18 years)
• 3. No known personal history of multiple sclerosis or related disorders
• 4. No other chronic diseases
• 5. Family members, unrelated household controls, or controls from the general population could be eligible