Derivatives of Omega-3 HUFA as Biomarkers of Traumatic Brain Injury

Exclusion Criteria

• •1. Unstable respiratory or hemodynamic status
• •2. Evidence of penetrating brain injury
• •3. Requirement for craniotomy or craniectomy
• •4. Evidence of serious infectious complications
• •5. Acute ischemic heart disease or abnormal heart rhythm
• •6. History of abnormality in liver function
• •7. History or evidence of active malignancy
• •8. History of diabetes
• •9. History of pre-existing neurologic disorder, such as dementia, uncontrolled epilepsy, multiple sclerosis, strokes, brain tumors, prior severe TBI, or other disorder that confounds interpretation neuropsychological results
• •10. History of pre-existing disabling Axis I psychiatric disorder, such as major depression, schizophrenia, bipolar disorder or dementia
• •11. Allergy to omega-3 fatty acid ethyl esters or any ingredient of the study agent.
• •12. Known allergy to Safflower seed oil or ragweed plants
• •13. Consumption of fish or seafood 3 or more times per week on average or regular administration of omega-3 supplements (e.g., cod liver oil, borage oil, fish oil or evening primrose oil) defined as an average of 250 mg/day of n-3 HUFAs, over the previous 3 months.
• •14. Pregnancy or breast-feeding
• •15. Prisoners or patients in custody
• •16. Allergy, hypersensitivity, or intolerance to fish oils or omega-3 fats which are found in fish.
• •17. Use of anticoagulant medications or aspirin more than once per week within the last three months
• •18. Enrollment in any concurrent research protocols that would interfere with participant safety or research data integrity.