Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Pennsylvania
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
1. Men and women, aged ≥18
2. CT evidence of TBI-linked abnormality
* Traumatic subarachnoid hemorrhage
* Intracerebral hemorrhage/contusion
* Subdural/epidural hematoma
3. Ability to undergo fNIRS testing with hypercapnia challenge
4. Subject able to provide informed consent
5. Attending of record agrees to include subject in study
You may not be if
1. Unstable respiratory or hemodynamic status
2. Evidence of penetrating brain injury
3. TBI requiring craniotomy or craniectomy
4. Evidence or risk of ICP crisis
5. History of disabling pre-existing neurologic disorder (e.g. dementia, uncontrolled epilepsy, multiple sclerosis, strokes, brain tumors, prior severe TBI, or other disorder that confounds interpretation of NIRS testing or neuropsychological results)
6. History of pre-existing disabling mental illness (e.g. major depression or schizophrenia)
* History of melanoma
* current use of organic nitrate vasodilators
* current use of ritonavir (HIV-protease inhibitor)
* current use of erythromycin, ketoconazole, or itraconazole; current use of cimetidine
* current use of alpha-blockers such as doxazosin (Cardura), tamsulosin (Flomax), and terazosin (Hytrin) prazosin (Minipres)
* resting hypotension (systolic BP \<90)
* severe renal insufficiency
* hepatic cirrhosis
* acute ischemic stroke within past 2 months
* acute myocardial infarction within past 2 months
* unstable angina pectoris
* acute or chronic heart failure
* retinitis pigmentosa
* pregnant or breastfeeding female
* known hypersensitivity or allergy to sildenafil
8. Unstable cardiac status that constitutes a contraindication to sexual activity
9. Inability to read and communicate in English (necessary to obtain reliable neuropsychometric data)
10. Nursing mothers
Clareo Health | Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury
