Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ottawa Hospital Research Institute
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with a diagnosis of a primary colorectal cancer and eligible for surgical resection.
Patients \> 18 years of age
Eligible patients must have signed a consent for surgical resection of the malignancy.
Ability to understand and provide a signed informed consent form (ICF) approved by the Research ethics board (REB).
Adequate kidney function with Creatine clearance\>30mL/min
Hemoglobin level \>90 mg/dL
Ability to comply with protocol requirements.
You may not be if
Prior adjuvant chemotherapy or radiation within 8 weeks of planned surgery.
Documented significant immunodeficiency due to underlying illness (e.g. HIV/AIDS) and/or medication (e.g. systemic corticosteroids, azathioprine, cyclosporin A). Subjects may be on physiologic doses of replacement prednisone or equivalent doses of corticosteroid (\<7.5 mg daily).
Subjects with resting hypotension (Blood pressure \<90/50 at rest).
History of autoimmune disease, such as but not restricted to, inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, or multiple sclerosis.
Serious intercurrent chronic or acute illness, or other illness considered by the investigator as an unwarranted high risk for an investigational product.
Active infection of any site and/or active herpes requiring ongoing treatment
Known pregnancy or nursing mothers
Subjects with a fish allergy.
Subjects with severe asthma defined as asthma not controlled with inhaled corticosteroids and additional controllers or by oral corticosteroid treatment (arginine can cause allergic response or make swelling in airways worse).
Subjects with a known inherited guanidinoacetate methyltransferase deficiency (due to an inability to convert arginine to creatine)
Subject with known history of liver cirrhosis
Subjects who have who have suffered a myocardial infarction or life-threatening arrhythmia within the last 6 months
Subjects with cardiac failure or coronary artery disease causing unstable angina
Subjects with a medical or psychological impediment to probable compliance with the protocol should be excluded.
