Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Nottingham
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Male or Female aged over 18 years.
Capacity to give informed consent
Normal blood pressure (systolic BP \> 100 mmHg and diastolic BP \> 70 mmHg)
Resting heart rate \> 50 bpm
For women, negative urinary β-hCG at the screening and subsequent visits
Subject able to hold breath for 10 seconds
Subject able to fit into 129Xe chest coil used for MRI
Subject able to understand the requirements of the study and to cooperate with the study procedures
HEALTHY VOLUNTEERS
No significant respiratory disease within the last year
PATIENTS
COPD
Evidence of airflow obstruction (FEV/FVC \<0.7) and FEV1 \<80% predicted post bronchodilator
Minimum FVC 1.5L
Subject not deemed fit enough to tolerate procedure
Subject deemed unsuitable by clinical investigator for other reasons
PATIENTS
Unsuitable for MRI scanning (e.g. have metal implants or pacemaker or contraindicated following questionnaire)
Acute respiratory illness within 30 days of MRI
Subject has received an IMP (not including hyperpolarized 129Xe) within 30 days of MRI and administration of 129Xe deemed inappropriate in context of other study
Subject deemed unlikely to comply with instructions during imaging
Subject not deemed fit enough to tolerate procedure
Subject deemed unsuitable by clinical investigator for other reasons
You may not be if
HEALTHY VOLUNTEERS
Unsuitable for MRI scanning (e.g. have metal implants or pacemaker or contraindicated following questionnaire)
Acute respiratory illness within 30 days of MRI
Subject has received an IMP (not including hyperpolarized 129Xe) within 30 days of MRI and administration of 129Xe deemed inappropriate in context of other study
Subject deemed unlikely to comply with instructions during imaging
Clareo Health | Functional MR Lung Imaging Using Hyperpolarised 129Xe
