Exenatide Once Weekly for Smoking Cessation

Exclusion Criteria

• •Meet criteria for the following psychiatric and/or substance use disorders as assessed by the Mini International Neuropsychiatric Interview (MINI): items C (current manic or hypomanic episode only), I (alcohol abuse - Alcohol Addendum-past 3 months only; current alcohol dependence), J (substance abuse -Substance Abuse Addendum - past 3 months only; current substance dependence), K (current psychotic disorder or current mood disorder with psychotic features).
• •Individuals who meet criteria for non-exclusionary psychiatric disorders that are considered clinically unstable and/or unsuitable to participate as determined by the Principal Investigator and/or Study Physician.
• •Individuals rated as moderate (9-16) to high (17 or greater) on suicidality as assessed by Module B of the MINI.
• •Have personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2;
• •Have type 1 diabetes mellitus;
• •Have severe cardiovascular disease (history of myocardial infarction, life-threatening arrhythmia, or worsening angina pectoris);
• •Have active temporomandibular joint disease;
• •Have severe gastrointestinal disease (i.e. severe gastroparesis);
• •Have previous history of pancreatitis or are at risk for pancreatitis;
• •Have creatinine clearance (CrCl) \< 30;
• •Have any previous medically adverse reaction to study medications, nicotine, or menthol;
• •Be pregnant or lactating or unwilling to provide a negative pregnancy test before study entry;
• •Not using a reliable form of contraception (e.g., abstinence, birth control pills, intrauterine device, condoms, or spermicide);
• •Have any illness which in the opinion of the primary investigator would preclude safe and/or successful completion of the study.