A Study of Chimeric Antigen Receptor T Cells Combined With Interventional Therapy in Advanced Liver Malignancy

Exclusion Criteria

• •Pregnant or lactating women
• •Concurrent use of systemic steroids. Recent or current use of inhaled steroids is not exclusionary
• •patients in the situation of: (1) 30 days before apheresis is still in the period of other antitumor drug observation; (2) patient dont recuperate from earlier acute adverse influence brought by any treatments accepted before
• •Four weeks before recruit accepted radiation therapy
• •Previously treatment with any gene therapy products
• •Feasibility assessment during screening demonstrates\<30% transduction of target lymphocytes, or insufficient expansion (\<5-fold) in response to CD3/CD28 costimulation
• •Any serious, uncontrolled diseases (including, but not limit to, unstable angina pectoris, congestive heart failure, grade III or IV cardiac disease, serious arrhythmia, liver and kidney disorders or metabolic diseases, CNS diseases)
• •Patient with severe acute hypersensitive reaction
• •Taking part in other clinical trials
• •Study leader considers not suitable for this tiral