Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Minnesota
Age
21–75
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Primary inclusion for spasmodic dysphonia:
1. Diagnosis of adductor spasmodic dysphonia
2. Symptoms at worst severity if receiving regular botulinum injections
Primary inclusion for healthy participants (controls):
1. Absence of vocal fold pathology
You may not be if
Primary exclusion for participants with spasmodic dysphonia:
1. Other forms of dystonia
2. Vocal fold pathology or paralysis
3. Diagnosis of voice tremor
4. Laryngeal surgery
5. Laryngeal cancer or neurological condition other than dystonia
6. Contraindication to TMS
7. Medications with effect on central nervous system
8. Inability to complete tasks associated with study
9. Adult lacking ability to consent
Primary exclusion for healthy participants (controls):
1. Any health condition or disability that would interfere with participation
2. Contraindications to TMS
3. Medications with effect on central nervous system
4. Adult lacking ability to consent
TMS contraindications:
The only absolute contraindication to TMS/rTMS is the presence of metallic hardware in close contact to the discharging coil (such as cochlear implants, deep brain stimulator, or medication pumps). In such instances there is a risk of inducing malfunctioning of the implanted devices.
Conditions classified as of increased or uncertain risk are listed below (Rossi et al., 2009; Rossini et al., 2015). Persons under those circumstances will be excluded from the study.
1. Pregnancy
2. Bipolar disorder
3. Epilepsy or history of seizure episodes in the past two years
4. Vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without history of seizure, and without anticonvulsant medication
5. Use of medications that potentially lower seizure threshold
