The Effects of BCRP Q141K on Allopurinol Pharmacokinetics and Dynamics

Exclusion Criteria

• •vascular disease
• •renal impairment
• •medications/supplements that affect uric acid levels
• •pregnant or lactating women
• •prior history of allergic reaction to allopurinol or testing positive for HLA-B\*5801 allele
• •risk of urinary or gastric retention or narrow-angle glaucoma
• •impaired hepatic function
• •evidence of anemia
• •evidence or diagnosis of congestive heart failure
• •smokers
• •subjects with a mutation other than rs2231142 in the ABCG2 genotype
• •subjects taking hormonal contraceptives or other hormonal medications
• •evidence of recreational drug use as determined by questionnaire