Xylitol for Otitis Media

Exclusion Criteria

• •History of immunodeficiency or an immunologic disorder that predisposes to frequent infections.
• •History of prior pressure-equalization (PE) tube placement and the tubes are still in place.
• •Active or recent (\<1 month prior to screening) middle ear disease, including but not limited to: cholesteatoma, tympanic membrane perforation, congenital external or middle ear abnormalities or malformations.
• •History of previous otologic surgery including tympanoplasty, and/or mastoidectomy.
• •Previous use of intranasal sprays other than normal saline, including intranasal steroids, and/or xylitol within 1 month prior to screening.
• •Any other clinically significant illness or medical condition, per PI discretion, that would prohibit the subject from participating in the study.
• •Subject has previously been randomized to a trial of Xylitol.
• •Parent/guardian is unable to administer the study nasal spray.
• •Parent/guardian is unable to read, write, and understand English.
• •Parent/guardian is unable to provide legally effective consent.