Aurinia Early Urinary Protein Reduction Predicts Response

Exclusion Criteria

• •Estimated glomerular filtration rate (eGFR) as calculated by the Chronic Kidney Disease Epidemiology Collaboration equation of ≤45 mL/min/1.73 m2 at screening
• •Currently requiring renal dialysis (hemodialysis or peritoneal dialysis) or expected to require dialysis during the study period.
• •A previous kidney transplant or planned transplant within study treatment period.
• •Malignancy within 5 years of screening, with the exception of basal and squamous cell carcinomas treated by complete excision. Subjects with cervical dysplasia that is cervical intraepithelial neoplasia 1, but have been treated with conization or loop electrosurgical excision procedure, and have had a normal repeat Papanicolaou smear test (PAP) are allowed.
• •Lymphoproliferative disease or previous total lymphoid irradiation.
• •Severe viral infection (such as Cytomegalovirus (CMV), Hepatitis B virus (HBV), Hepatitis C virus (HCV)) within 3 months of screening; or known human immunodeficiency virus infection.
• •Active tuberculosis (TB), or known history of TB/evidence of old TB if not taking prophylaxis with isoniazid.
• •Other known clinically significant active medical conditions, such as:
• •Severe cardiovascular disease including congestive heart failure, history of cardiac dysrhythmia or congenital long QT syndrome. QT interval duration corrected for heart rate using method of Fridericia (QTcF) exceeding 480 msec in the presence of a normal QRS interval (\<110 msec) at time of screening will result in exclusion.
• •Liver dysfunction (aspartate aminotransferase, alanine aminotransferase, or bilirubin greater than 2.5 times the upper limit of normal) at screening and confirmed before enrollment.
• •Chronic obstructive pulmonary disease or asthma requiring oral steroids.
• •Bone marrow insufficiency unrelated to active systemic lupus erythematosus (SLE) (according to Investigator judgment) with white blood cell count \<2,500/mm3; absolute neutrophil count \<1.3 × 103/μL; thrombocytopenia (platelet count \<50,000/mm3).
• •Active bleeding disorders.
• •Current infection requiring IV antibiotics.