Efficacy and Safety of Prurisol Administered Orally for Active Moderate to Severe Chronic Plaque Psoriasis

Exclusion Criteria

• •1. Positive blood test for HLA-B\*5701 allele
• •2. Currently have forms of psoriasis other than chronic plaque-type, (e.g., guttate, erythrodermic, exfoliative, palmoplantar, pustular), with the exception of nail psoriasis
• •3. Evidence of drug-induced psoriasis, e.g., a new onset or current exacerbation of psoriasis from beta-blockers, calcium channel inhibitors, antimalarial drugs or lithium
• •4. Psoriasis flare or rebound within 4 weeks prior to Screening
• •5. Active inflammatory diseases other than psoriasis that might confound the evaluation of study treatment on signs and symptoms of psoriasis.
• •6. . Any of the following prohibited treatments that do not meet the specified minimum washout period:
• •1. Biologic immunomodulating treatments of brodalumab or ustekinumab within 24 weeks prior to start of study treatment
• •2. Biologic immunomodulating treatments such as adalimumab, etanercept, infliximab, ixekizumab, secukinumab or certolizumab pegol within 12 weeks prior to start of study treatment
• •3. Systemic immunomodulating treatments other than biologics within 4 weeks prior to start of study treatment, e.g., oral corticosteroids, injectable corticosteroids (intraarticular, intramuscular, cutaneous/subcutaneous or intravenous), methotrexate, cyclosporine, cyclophosphamide, apremilast
• •* Inhaled or intranasal corticosteroids with predominantly local effect (e.g., to treat asthma) are allowable
• •* Use of corticosteroids in the eye or the ear are allowable
• •4. Other systemic treatments for psoriasis within 4 weeks prior to start of study treatment, e.g., retinoids, fumarates
• •* Any such treatment used to treat a symptom of psoriasis but not the condition itself (e.g., anti-histamines for pruritus) is not restricted
• •5. Photochemotherapy, e.g., Psoralens + UVA phototherapy (PUVA), within 4 weeks prior to start of study treatment
• •6. Phototherapy, e.g., UVA, UVB, within 2 weeks prior to start of study treatment
• •7. Topical treatments that could affect signs and symptoms of psoriasis within 2 weeks prior to start of study treatment, e.g., corticosteroids, vitamin D analogs, retinoids, pimecrolimus, tacrolimus, tars, keratolytics
• •* Allowable exceptions are: low or least potent (Class 6 or 7) topical corticosteroids for use on face, palms, soles, and intertriginous areas only; tar and salicylic acid preparations/shampoos for use on scalp only; bland emollient for use on any body region
• •7. Past vaccination with live vaccine within 6 weeks prior to start of study treatment, or plans for administration during the study
• •8. Any investigational or experimental therapy or procedure or participation in any interventional trial within 4 weeks or 5 half-lives (whichever is longer) prior to start of study treatment
• •9. Women of child-bearing potential who are not using reliable means of contraception, e.g., abstinence, surgical sterilization (hysterectomy and/or bilateral oophorectomy or partner vasectomy) or tubal ligation, double barrier method, oral/ injected/ implanted/ transdermal hormonal contraception, intrauterine device or intrauterine system, throughout study participation, and for 4 weeks after the end of treatment
• •10. Women of child-bearing potential who are pregnant or nursing (lactating), or planning a pregnancy while participating in the study
• •11. History of any ongoing, chronic or recurrent infectious disease (with the exception of episodic herpes labialis and herpes genitalis, and vaginal yeast infections)
• •12. Evidence of tuberculosis infection as defined by a positive QuantiFERON®-TB Gold In-Tube test (QFT-G) at Screening, or subjects with an indeterminate QFT-G test result with any retest result as indeterminate or positive
• •13. History of either untreated or incompletely treated latent or active tuberculosis infection
• •14. Ongoing or recent history of any non-psoriatic uncontrolled (in the Investigator's medical opinion) systemic disease, including, but not limited to renal, hepatic, hematologic, gastrointestinal, endocrine, metabolic, pulmonary, cardiac, neurologic, or psychiatric disease. (e.g., A past or current history of hypertension that is controlled with diet and/or medications is not exclusionary.)
• •15. History of lymphoproliferative disease or any known malignancy or history of malignancy of any organ system within the past 5 years with the exception of: basal cell or squamous cell carcinoma or actinic keratoses that have been treated or excised with no evidence of recurrence in the past 12 weeks; cervical carcinoma in situ or non-invasive malignant colon polyps that have been removed
• •16. Active systemic infections during the past two weeks (exception: common cold) prior to start of study treatment or any infection that reoccurs on a regular basis
• •17. Past medical history of infection with HIV, hepatitis B or hepatitis C
• •18. History of any allergic reaction to any formulation of abacavir
• •19. Previous treatment with any abacavir-containing product, e.g., Ziagen®, Epzicom®, or Trizivir®
• •20. Previous participation in a clinical study of Prurisol
• •21. Presence of any medical or psychiatric condition that, in the Investgator's opinion, makes it unlikely that the requirements of the protocol will be completed
• •22. History of alcohol or substance abuse, unless in full remission for more than 6 months prior to start of study treatment
• •23. Electrocardiogram (ECG) obtained at Screening visit which shows medically relevant abnormalities which may affect subject safety or interpretation of study results
• •24. Observed clinical laboratory values/abnormalities during Screening that show any one or more of the following:
• •1. Screening total white blood cell (WBC) count \<2.5 x 10\^9/L, or platelets \<100 x 10\^9/L or neutrophils \<1.2 x 10\^9/L or hemoglobin \<8.5 g/dL
• •2. Screening serum creatinine level exceeding 2.0 mg/dL (176.8 µmol/L)
• •3. Screening alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels \> 2 x ULN
• •25. Any other severe acute or chronic medical or psychiatric condition or test abnormality(ies) that, in the Investigator's opinion, puts the subject at significant risk, could confound the study results, or may interfere significantly with the subject's participation in the study