Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Baylor College of Medicine
With
Shire
One hundred and twenty subjects will be enrolled. Adolescent females with heavy menstrual bleeding (HMB) and low Von Willebrand Factor (VWF) will be recruited.
Data collection will occur from participant's medical records in regards to their low VWF activity and HMB medical history.
Participants will be asked to complete symptom questionnaires in regards to their HMB.
A blood sample will be collected to analyze how many participants have the disease causing sequence variation in the VWF gene and other genes affecting bleeding, clotting and blood vessel biology and correlated with their bleeding history.
The blood sample will be deidentified and stored indefinitely for future research.
Age
0–21
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Post-menarchal females less than 21 years of age
HMB defined as PBAC score greater than 100
VWF:Activity more than or equal to 30 and less than or equal to 50 IU/dL x 2
VWF: Activity /VWF:Ag ratio greater than or equal to 0.6
Normal VW multimers, if performed
You may not be if
Post menarchal females age greater than or equal to 21 years
VWF: Activity less than 30 or greater than 50 IU/dL consistently, type 2 or type 3 VWD
Presence of other bleeding disorders (thrombocytopenia, platelet function defect, coagulation factor deficiency, fibrinogen defect or deficiency)
