Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia

Exclusion Criteria

• •Patient has had any prior esophageal, periesophageal, or gastric surgery, or treatment with sclerosing agent.
• •More than 1 pneumatic dilation procedure to a diameter of \> 2 cm in their lifetime.
• •Pneumatic dilation procedure to a diameter of \> 2 cm within 1 year prior to randomization. Prior bougie dilation(s) or pneumatic dilation(s) ≤ 2 cm are allowed.
• •Prior esophageal injection of botulinum toxin (Botox) within 6 months prior to randomization or more than 2 esophageal Botox injection procedures in their lifetime.
• •Patients with malignant or premalignant esophageal lesions.
• •Patient has taken any drug that can affect gastrointestinal (GI) motility in the 72 hours before check-in through discharge from the clinic.