1. Minimum of 10% liver fat as assessed by MRI - Proton Density Fat Fraction

2. Fasting serum LDL-C \>130 mg/dL at screening, \>110 mg/dL on lipid lowering medications

3. Any one of the following:

1. Triglycerides ≥150 mg/dL or receiving prescription medication for elevated triglycerides.

2. Systolic blood pressure \>130 mmHg or diastolic blood pressure ≥85 mmHg or receiving prescription medication for hypertension.

3. Waist circumference \>40 inches (men) or \>35 inches (women)

4. Body mass index (BMI) 18.50 - 40.00 kg/m2 inclusive at screening

5. Provide a personally-signed and dated informed consent document

Safety and Tolerability of VK2809 in Patients With Primary Hypercholesterolemia and Non-Alcoholic Fatty Liver Disease