Effect of Colchicine on Range of Motion After Manipulation Under Anesthesia for the Stiff Total Knee Replacement

Exclusion Criteria

• •Patients who are wheelchair bound
• •Patients requiring concomitant arthroscopic or open procedures
• •Revision TKA
• •Patients requiring bilateral MUA
• •Patients with renal disease (Creatinine \> 1.5, and/or estimated creatinine clearance less than 30 mL/min)
• •Patients with hepatic disease (known liver disease, cirrhosis, and/or AST/ALT\>60)
• •Patients concurrently taking strong CYP3A4 inhibitors:
• •* Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, amprenavir, aprepitant, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, verapamil
• •Patients concurrently taking strong P-glycoprotein inhibitors:
• •* Cyclosporine, ranolazine
• •Patients concurrently taking medications that increase the risk for myopathy and rhabdomyolysis:
• •* atorvastatin, fluvastatin, pravastatin, simvastatin, fibrates, gemfibrozil, digoxin
• •Patients with a history of blood dyscrasias
• •Pregnant patients
• •Patients who are nursing mothers
• •Patients with reported allergy to colchicine
• •Non-English speaking patients