Observational Natural History Study of Autosomal Dominant Retinitis Pigmentosa (adRP)

Exclusion Criteria

• •1. The subject is participating in an interventional clinical trial or has participated in an interventional clinical trial within 90 days of screening; participation in non-interventional observational studies is permitted.
• •2. The subject has received treatment or has been in the treatment arm of a clinical trial for gene therapy, stem cell therapy, retinal progenitor cell therapy, tissue transplantation, device or drug delivery implantation, or other similar invasive therapy.
• •3. The subject has any of the following medical conditions that will interfere with consistent follow-up over any part of the study:
• •1. Stroke
• •2. Severe or unstable coronary disease
• •3. End-stage or aggressive malignancy
• •4. General poor health or uncontrolled or severe disease (eg, cardiovascular, neurological, psychological, pulmonary,renal, hepatic, endocrine, or gastrointestinal disorders) that in the opinion of the investigator would interfere with participation in the study
• •4. The subject has any of the following ocular conditions that could interfere with or confound follow-up of disease progression:
• •* Glaucoma
• •* Diabetic retinopathy
• •* Choroidal neovascularization
• •* Retinal inflammatory disease
• •* Cataract worse than grade 2 (nuclear, posterior subcapsular \[PSC\], or cortical)
• •* High myopia (≥8 diopters)
• •* Herpes simplex virus of the eye
• •* Acute infection or inflammation
• •* Any ocular condition that in the opinion of the investigator would interfere with the ability to assess retinal morphology and functionality
• •5. The subject has had intraocular surgery within 90 days prior to screening.
• •6. The subject currently requires the following protocol prohibited medications or has ingested such medication within 30 days of screening:
• •Plaquenil Thioridazine Clofazimine Deferoxamine Phenothiazine Chlorpromazine Cisplatin Valproic acid Any other drugs with known visual side effects
• •7. The subject has 3 first- or second-degree family members already enrolled in the study.