Cardiac conduction abnormalities (e.g. AV-conduction abnormalities)

History of epilepsy

Recent history of myocardial infarction (2 months)

Metallic biliary stent that is not removable prior to procedure by endoscopy and within the ablation field

Evidence of distant metastasis (e.g. liver, lung, peritoneum)

Informed consent cannot be given by the patient

Known hypersensitivity to the IRE electrodes (stainless steel 304L)

Women of childbearing potential who are pregnant, breast feeding, or not taking an adequate method of contraception at the time of procedure

Quality of Life After in Situ IRE in Locally Advanced Pancreatic Cancer