Treatment of Diabetes in Patients With Systolic Heart Failure

Exclusion Criteria

• •Type I diabetes;
• •Open label treatment with Sodium-GLucose coTransporter (SGLT)-2 inhibitors (within the past 3 months);
• •Current treatment with thiazolidinedione (within the past 3 months);
• •Chronic Renal Disease defined as Glomerular Filtration Rate (GFR) \<50 ml•min-1/1.73m2 according to local laboratory
• •Pregnancy or of child-bearing potential or lactating;
• •Active or recent (within 2 weeks) genital/urinary infection;
• •Concomitant conditions or treatment which would affect completion or interpretation of the study (i.e, physical inability to walk or run on a treadmill
• •Inability to give informed consent.
• •Estimated GFR \<60 ml•min-1/1.73m2
• •Implantable cardioverter defibrillator, pacemaker or other implantable metal device not compatible with CMR scanning;
• •Severe claustrophobia, inability to lay flat for up to 60 minutes, or other contraindication to CMR scanning.