Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty

Inclusion Criteria

• •1. Premature appearance of secondary sexual characteristics: girls present with development of secondary sexual characteristics before 8, with breast induration as the earliest manifestation.
• •2. Accelerated linear growth: the annual growth rate is higher than normal.
• •3. Advanced bone age: the bone age is 1 or years more than the actual age
• •4. Enlargement of sexual glands: B-mode ultrasonography of pelvic cavity indicates the volumes of the uterus and ovaries have increased, and multiple ovarian follicles with a diameter\>4mm can be found in ovaries;
• •5. HPGA functions have been primed; serum gonadotropin and sexual hormone levels reach pubertal values.
• •6. Subjects should be willing and able to follow the study protocol during the study period.
• •7. Subjects should submit their parents' or guardians' written informed consent before initiation of the study procedure with non-normal medical care. They should understand that subjects or their parents/guardians may withdraw the consent at any time without impairing future medical care. If the child is old enough to read and write, she should submit a separate consent form.