Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG

Inclusion Criteria

• •1. Age less than or equal to 75 years
• •2. The patient must be approved for transplant by the treating transplant physician. This includes completion of their pretransplant workup, as directed by standard Dartmouth-Hitchcock Medical Center (DHMC) Standard Operating Procedures (SOPs). DHMC SOP for Pretransplant Evaluation of allogeneic recipient.
• •3. The patient must have a disease, listed below, with treatment responsiveness that the treating transplant physician believes will benefit from an allogeneic stem cell transplant. The diseases include:
• •1. Acute leukemia AML (Acute Myeloid Leukemia), ALL (Acute Lymphoid Leukemia)
• •2. Chronic leukemia CML (Chronic Myeloid Leukemia), CLL (Chronic Lymphoid Leukemia)
• •3. Myelodysplasia
• •4. Myelofibrosis
• •5. Lymphoma NHL (Non-Hodgkin's Lymphoma) and Hodgkin's disease
• •6. Plasma cell disorder, including myeloma, Waldenstrom's Macroglobulinemia
• •4. Donor availability- the patient must have an identified donor
• •1. Sibling Availability of a 6 out of 6 identical donor
• •2. Unrelated donor: Availability of a 6 out of 6 unrelated donor
• •5. No human immunodeficiency virus (HIV) infection or active hepatitis B or C
• •6. Easter Cooperative Oncology Group (ECOG) performance status 0, 1, or 2
• •7. Diffusing capacity of the lungs for carbon monoxide DLCO more than or equal to 40 percent predicted
• •8. Left ventricular ejection fraction more than or equal to 35 percent
• •9. Serum bilirubin less than 2x upper limit of normal transaminases less than 3x normal at the time of transplant
• •10. No active or uncontrollable infection
• •11. In female, a negative pregnancy test if experiencing menstrual periods
• •12. No major organ dysfunction precluding transplantation
• •13. No evidence of an active malignancy that would limit the patient's survival to less than 2 years. If there is any question, the principal investigator can make a decision.